Medical

Leser-Trélat sign

The “Leser-Trélat sign” refers to the sudden appearance or rapid increase in the number and size of seborrheic keratoses (a type of benign skin tumor) associated with an internal malignancy, typically adenocarcinomas of the gastrointestinal tract.

This sign is named after Edmund Leser and Ulysse Trélat, who independently described the phenomenon in the 19th century. The appearance of numerous seborrheic keratoses can sometimes be an indication of an underlying cancer, although it’s essential to note that not all cases of Leser-Trélat sign are associated with malignancy, and not all cancers manifest with this sign.

If someone develops a sudden onset of multiple seborrheic keratoses, especially if accompanied by other symptoms suggestive of an underlying malignancy, it’s crucial to seek medical evaluation promptly. The presence of the Leser-Trélat sign may warrant further investigation to rule out or diagnose any associated cancer.

Other severe medical conditions related to keratosis

Keratosis pilaris is typically considered a benign and harmless skin condition. However, in rare cases, it may be associated with certain medical conditions or syndromes. Here are a few examples:

1. Atopic Dermatitis (Eczema): Some individuals with keratosis pilaris may also have atopic dermatitis, a chronic inflammatory skin condition characterized by dry, itchy skin and eczema-like rashes.
2. Ichthyosis: In some cases, keratosis pilaris may occur in conjunction with ichthyosis, a group of genetic skin disorders characterized by dry, scaly skin.
3. Netherton Syndrome: This rare genetic disorder involves abnormal development of the skin and hair. Individuals with Netherton syndrome may experience symptoms such as ichthyosis, eczema, and hair shaft abnormalities, which can resemble severe cases of keratosis pilaris.
4. Keratosis Pilaris Atrophicans (KPA): This is a rare subtype of keratosis pilaris characterized by follicular papules, atrophy (thinning) of the skin, and scarring. KPA may be associated with various underlying medical conditions, including autoimmune diseases.
5. Nutritional Deficiencies: While not directly related to keratosis pilaris, deficiencies in certain vitamins or nutrients, such as vitamin A or essential fatty acids, can affect skin health and contribute to skin conditions like keratosis pilaris.

It’s important to note that these associations are relatively uncommon, and the vast majority of individuals with keratosis pilaris do not have any underlying severe medical conditions. If you suspect you may have keratosis pilaris or are concerned about any associated symptoms, it’s best to consult with a dermatologist for proper evaluation and management.